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Published on: November 5, 2019
Bacterial meningitis after MMR immunisation
F A Riordan1, J A Sills, A P Thomson
1University of Liverpool, UK.
Postgraduate Medical Journal
|December 1, 1995
Abstract:
Two children developed bacterial meningitis within five days of measles-mumps-rubella (MMR) immunisation. Diagnosis was delayed because symptoms were attributed to the vaccine, although both had a raised C-reactive protein. Fever or rash within five days of MMR vaccination are unlikely to be due to the vaccine and a raised C-reactive protein suggests bacterial infection.
Insights
Bacterial meningitis can occur shortly after measles-mumps-rubella (MMR) vaccination. A high C-reactive protein indicates bacterial infection, not a vaccine reaction, prompting timely diagnosis and treatment.
Area of Science:
- Pediatrics
- Infectious Diseases
- Immunology
Background:
- Measles-mumps-rubella (MMR) vaccination is a common childhood immunization.
- Prompt diagnosis of bacterial meningitis is crucial for effective treatment and improved outcomes.
Observation:
- Two pediatric cases of bacterial meningitis were diagnosed within five days of MMR immunisation.
- Initial symptoms were mistakenly attributed to the MMR vaccine, delaying diagnosis.
Findings:
- Fever or rash within five days post-MMR vaccination are generally not vaccine-related adverse events.
- Elevated C-reactive protein levels in conjunction with these symptoms strongly suggest bacterial infection.
Implications:
- Healthcare providers should maintain a high index of suspicion for bacterial meningitis in children presenting with fever or rash post-MMR vaccination.
- Accurate interpretation of C-reactive protein levels is vital to differentiate vaccine reactions from serious bacterial infections.
- Timely diagnosis and appropriate antibiotic treatment are essential for managing bacterial meningitis in this context.
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