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Scleroderma and occupational exposure

M Bovenzi1, F Barbone, A Betta

  • 1Institute of Occupational Health, University of Trieste, Italy.

Scandinavian Journal of Work, Environment & Health
|August 1, 1995
PubMed
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Occupational exposure to organic solvents and silica is linked to scleroderma, a rare connective tissue disease. This case-referent study highlights the importance of workplace factors in scleroderma

Area of Science:

  • Occupational Medicine
  • Rheumatology
  • Epidemiology

Background:

  • Scleroderma is a rare connective tissue disease with potential occupational links.
  • Previous case reports suggest a role for occupation in scleroderma etiology.

Purpose of the Study:

  • To investigate the association between occupational exposures and scleroderma (systemic and localized variants).

Main Methods:

  • A case-referent study was conducted in Trento, Italy.
  • 21 scleroderma cases were identified (1976-1991) and matched with two referents each.
  • Interviews using a structured questionnaire assessed exposure to organic solvents, silica, and hand-arm vibration.

Main Results:

  • A significant association was found between organic solvent (aromatic hydrocarbon) exposure and scleroderma (OR 9.28).

Related Experiment Videos

  • An association between silica exposure and scleroderma was observed in men (OR 5.20).
  • Women showed an association between other chemical exposures and scleroderma (OR 2.11).

    • Conclusions:

    • Findings support the role of occupation in scleroderma etiology.
    • Exposure to organic solvents and silica is confirmed as associated with scleroderma.
    • Highlights the need for awareness of occupational risks in connective tissue diseases.