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Related Experiment Videos

Osteoarthritis. A continuing challenge

K E Sack1

  • 1Program in Rheumatology, University of California, San Francisco (UCSF), School of Medicine 94143-0326, USA.

The Western Journal of Medicine
|December 1, 1995
PubMed
Summary
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Osteoarthritis, a common cartilage disorder, affects most older adults. While wear and tear contributes, other factors like genetics and diet are involved, and current treatments offer limited benefits.

Area of Science:

  • Rheumatology
  • Orthopedics
  • Biochemistry

Background:

  • Osteoarthritis (OA) affects a vast majority of the population by age 75.
  • Current diagnostic criteria lack rigor, hindering precise prevalence determination.
  • The 'wear and tear' theory inadequately explains all OA manifestations and biochemical changes.

Purpose of the Study:

  • To review the multifactorial nature of osteoarthritis.
  • To evaluate current treatment modalities for osteoarthritis.
  • To discuss potential therapeutic targets and surgical interventions for OA.

Main Methods:

  • Literature review of osteoarthritis pathogenesis and treatment.
  • Analysis of clinical and biochemical findings in osteoarthritic cartilage.

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  • Evaluation of non-steroidal anti-inflammatory drugs (NSAIDs) and other pharmacologic agents.

    • Main Results:

    • Heredity, hormones, and diet are implicated as contributing factors to OA.
    • NSAIDs may offer no superior pain relief compared to analgesics and can negatively impact cartilage.
    • Chondrolytic enzyme inhibitors show promise in animal models but lack human validation.

    Conclusions:

    • Osteoarthritis is a complex disorder with multifactorial etiology.
    • Current OA treatments have limitations, with potential risks associated with NSAIDs.
    • Further research into novel therapeutic agents and surgical options is warranted for effective OA management.