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The effect of vasopressin analogue [d(CH2)5(1),Tyr(Me)2]AVP on memory process in rats with experimental amnesia
H Car1, M Borawska, K Wiśniewski
1Department of Pharmacology, Medical Academy, Białystok, Poland.
Acta Neurobiologiae Experimentalis
|January 1, 1995
Abstract:
We investigated the effect of a single 2 micrograms dose of vasopressin (AVP) analogue [(CH2)5(1),Tyr(Me)2]AVP on the processes of retrieval of conditioned reflexes in rats with experimentally induced amnesia. The models used were: electroconvulsive shock (ECS) and hypoxia. It severely impaired the memory processes. The AVP analogue [d(CH2)5(1),Tyr(Me)2]AVP facilitated retrieval of passive avoidance in all animals.