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Identification of polymorphism at the glutathione S-transferase, GSTM3 locus: evidence for linkage with GSTM1*A
A Inskip1, J Elexperu-Camiruaga, N Buxton
1Department of Neurosurgery, North Staffordshire Hospital, Stoke-on-Trent, Staffordshire, U.K.
The Biochemical Journal
|December 15, 1995
Abstract:
Allelism in the glutathione S-transferase, GSTM3 gene has been identified using PCR with specific primers to exon 6/exon 7. Sequencing showed the mutant GSTM3*B allele to have a three-base deletion in intron 6 with a frequency of 0.158. The mutation generates a recognition sequence, 5'-AAGATA-3', for the negative transcription factor YY1. GSTM3*B was significantly associated with GSTM1*A.