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Effect of magnetic fields on rodent monooxygenase enzymes
R Del Carratore1, E Morichetti, C Della Croce
1Istituto di Mutagenesi e Differenziamento CNR, Pisa, Italy.
Bioelectromagnetics
|January 1, 1995
Abstract:
The effects of 50 Hz, 1.2 mT magnetic fields (MFs) were tested on hepatic monooxygenase enzymes of basal and beta-naphthoflavone-phenobarbital-preinduced rats and mice. An inductive effect on cytochrome P-450 level and on some enzymatic cytochrome P-450-dependent activities was observed in basal mice after MF exposure. Enzymatic activities in preinduced mice and rats were reduced by MFs, the degree of reduction depending on the enzyme. A specific inhibitory effect was determined in some of the assayed activities and in the relative peculiar P-450 isoforms detected by Western blot analysis.