Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intact delay-eyeblink classical conditioning in amnesia

J D Gabrieli1, R McGlinchey-Berroth, M C Carrillo

  • 1Memory Disorders Research Center, Boston University School of Medicine, USA.

Behavioral Neuroscience
|October 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Meaningfulness in Alzheimer's Disease Clinical Trials. A Report from the EU-US CTAD Task Force.

The journal of prevention of Alzheimer's disease·2024
Same author

CTAD Task Force Paper: Neuropsychiatric Symptoms in AD: Clinical Trials Targeting Mild Behavioral Impairment: A Report from the International CTAD Task Force.

The journal of prevention of Alzheimer's disease·2024
Same author

Viewpoint: Defining FDA Approved Treatments as Reasonable and Necessary: Perspectives of Individuals Living with Alzheimer's Disease and Care Partners.

The journal of prevention of Alzheimer's disease·2023
Same author

Can We Use Blood Biomarkers as Entry Criteria and for Monitoring Drug Treatment Effects in Clinical Trials? A Report from the EU/US CTAD Task Force.

The journal of prevention of Alzheimer's disease·2023
Same author

Editorial: The Future is Now: Advancing Blood-Based Markers.

The journal of prevention of Alzheimer's disease·2022
Same author

The Ups and Downs of Amyloid in Alzheimer's.

The journal of prevention of Alzheimer's disease·2022

Human amnesic patients show normal classical conditioning of eyeblink responses. This suggests that brain structures vital for declarative memory are not essential for forming basic conditioned stimulus-unconditioned stimulus associations.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Behavioral Science

Background:

  • Classical conditioning is a fundamental form of associative learning.
  • The role of declarative memory structures in classical conditioning in humans remains debated.
  • Previous research suggests parallels between human and animal models of conditioning.

Purpose of the Study:

  • To investigate the capacity for classical conditioning in human amnesic patients.
  • To determine if brain structures critical for declarative memory are necessary for acquiring elementary associations.

Main Methods:

  • Eyeblink classical conditioning paradigm using a tone (CS) and airpuff (US).
  • Comparison of conditioning acquisition and extinction between 7 amnesic patients and 7 matched controls.

Related Experiment Videos

  • Assessment of baseline pseudoconditioning performance.

    • Main Results:

    • Amnesic patients demonstrated normal acquisition and extinction of conditioned eyeblink responses.
    • Performance in terms of response number, latency, and magnitude was comparable to controls.
    • Baseline pseudoconditioning performance was also normal in amnesic patients.

    Conclusions:

    • Declarative memory structures are not essential for the acquisition of elementary conditioned stimulus-unconditioned stimulus associations in humans.
    • Findings support the dissociation between declarative memory and basic associative learning.
    • Human classical conditioning capabilities are preserved despite significant declarative memory impairments.