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Anti-Ro/SSA-associated annular erythema in childhood
S Miyagawa1, T Iida, T Fukumoto
1Department of Dermatology, Nara Medical University, Japan.
The British Journal of Dermatology
|November 1, 1995
Insights
Annular erythema in children can indicate Sjögren's syndrome, an autoimmune condition. Early detection of this rare pediatric disease is crucial for timely management and monitoring.
Area of Science:
- Pediatric Rheumatology
- Autoimmune Diseases
- Dermatology
Background:
- Sjögren's syndrome is a chronic autoimmune disorder primarily affecting exocrine glands.
- Pediatric Sjögren's syndrome is considered rare, with limited reported cases in children.
- Anti-Ro/SSA antibodies are frequently associated with Sjögren's syndrome.
Observation:
- Four children with anti-Ro/SSA antibodies presented with annular erythema.
- Cutaneous lesions were observed in all affected children.
- One child also experienced aseptic meningoencephalitis alongside skin manifestations.
Findings:
- Annular erythema can be a presenting sign of Sjögren's syndrome in pediatric patients.
- The presence of anti-Ro/SSA antibodies supports the diagnosis in these cases.
- Concurrent neurological involvement, such as meningoencephalitis, can occur.
Implications:
- Children presenting with annular erythema warrant thorough evaluation for Sjögren's syndrome.
- Increased awareness of Sjögren's syndrome in children is needed.
- Early diagnosis and management are essential for improving outcomes in pediatric Sjögren's syndrome.
Abstract:
We report four children with anti-Ro/SSA positive who presented with an annular erythema as a manifestation of Sjögren's syndrome. One patient had an aseptic meningoencephalitis as well as cutaneous lesions. Children with annular erythema should be carefully followed for features of Sjögren's syndrome, which is believed to be a rare condition in children.