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Related Experiment Videos

Anaerobic threshold in total artificial heart animals

B Y Chiang1, G Pantalos, G L Burns

  • 1Artificial Heart Research Laboratory, University of Utah, Salt Lake City 84103-1414, USA.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|July 1, 1994
PubMed
Summary

Total artificial heart (TAH) animals show a low anaerobic threshold, indicating insufficient TAH performance for vigorous exercise. Optimizing TAH control systems may improve functional capacity.

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Area of Science:

  • Cardiovascular Physiology
  • Biomedical Engineering
  • Exercise Science

Background:

  • The anaerobic threshold is a key indicator of functional capacity, crucial for assessing cardiopulmonary function.
  • Total artificial hearts (TAHs) are vital for end-stage heart failure but their functional capacity during exercise requires thorough evaluation.

Purpose of the Study:

  • To determine the anaerobic threshold in animals with TAHs.
  • To evaluate the exercise performance of the TAH system in vivo.

Main Methods:

  • Five animals with TAHs underwent incremental exercise testing (2.0-4.5 km/hr) after a period of exercise training.
  • Anaerobic threshold was assessed using both lactate and CO2 production methods.

Main Results:

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  • The anaerobic threshold was measured at 6.72 ± 0.84 ml/kg/min (lactate method) and 6.48 ± 0.79 ml/kg/min (CO2 method).
  • These values suggest that the TAH's performance is insufficient to meet the metabolic demands of intense skeletal muscle activity during exercise.

Conclusions:

  • The current TAH system's performance capacity is limited, hindering vigorous exercise in TAH animals.
  • Future TAH control systems could benefit from automatic modes and integrated oxygen metabolism indices (delivery, consumption, extraction) to enhance functional capacity.