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Related Experiment Videos

A disposable, coated wire heparin sensor

J H Yun1, B Fu, M E Meyerhoff

  • 1College of Pharmacy, University of Michigan, Ann Arbor 48109-1065, USA.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|July 1, 1994
PubMed
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A new disposable heparin sensor was developed using a coated-wire design for rapid clinical measurements. Optimized membrane thickness enhances potentiometric response, enabling quick heparin monitoring in plasma and blood samples.

Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Materials Science

Background:

  • Heparin monitoring is crucial in clinical settings.
  • Existing methods can be time-consuming or require large sample volumes.
  • Development of rapid, disposable sensors is needed for point-of-care testing.

Purpose of the Study:

  • To develop an inexpensive, disposable heparin sensor using coated-wire technology.
  • To optimize sensor performance by varying membrane thickness.
  • To evaluate the sensor's utility in clinical applications like protamine titration.

Main Methods:

  • A polymer membrane doped with tridodecylmethylammonium chloride was formulated.
  • Copper wires were dip-coated with the membrane to create sensors.

Related Experiment Videos

  • Sensors with varying membrane thicknesses were tested for potentiometric response.
  • Sensor performance was evaluated in undiluted plasma and during protamine titration.

    • Main Results:

    • Increasing membrane thickness enhanced potentiometric response but increased response time.
    • Optimized sensors showed significant and reproducible responses to heparin in plasma (0.5-12 units/ml).
    • Heparin sensor-determined titration end-points correlated well with activated partial thromboplastin time (aPTT) assay results.

    Conclusions:

    • The coated-wire heparin sensor is a viable disposable device for rapid heparin measurement.
    • The sensor demonstrates potential for real-time monitoring during procedures like protamine titration.
    • Further studies are needed to validate performance in whole blood samples.