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Microporous polymer surfaces prepared by an excimer laser ablation technique

Y Nakayama1, T Matsuda

  • 1Department of Bioengineering, National Cardiovascular Center Research Institute, Osaka, Japan.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|July 1, 1994
PubMed
Summary

This study introduces an excimer laser method for creating microporous polymer surfaces. This technique enhances cell ingrowth and improves elastomeric properties in materials like polyurethane, crucial for biomedical applications.

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Laser Physics

Background:

  • Developing advanced materials with controlled surface topography is essential for biomedical applications.
  • Microporous structures can significantly influence cell behavior and material properties.

Purpose of the Study:

  • To present an excimer laser microprocessing method for creating microporous polymer surfaces.
  • To investigate the relationship between laser parameters and ablation characteristics.
  • To evaluate the in vitro performance of micropored polymers for potential biomedical applications.

Main Methods:

  • Utilized a KrF excimer laser (248 nm) for ablative photodecomposition of polymer films.
  • Employed an optical microscope for precise laser irradiation and micropositioning.

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  • Controlled laser fluence, pulse number, and irradiated area size.
  • Analyzed surface composition using X-ray photoelectron spectroscopy (XPS).

    • Main Results:

    • Ablation depth showed a linear increase with accumulated laser pulses.
    • Surface chemical composition remained consistent regardless of pulse accumulation.
    • Achieved excellent micropore structuring quality on polyurethane, polyimide, and polycarbonate films.
    • Demonstrated rapid in vitro cell ingrowth on micropored polyurethane films (pore sizes from microns to tens of microns).
    • Observed enhanced elastomeric properties with higher micropore density.

    Conclusions:

    • Excimer laser ablation is an effective method for fabricating well-defined microporous polymer surfaces.
    • The developed technique offers precise control over pore characteristics and material properties.
    • Micropored polyurethane films show promise for biomedical applications due to enhanced cell integration and mechanical performance.