Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Surface modifying additives for improved device-blood compatibility

C C Tsai1, R M Deppisch, L J Forrestal

  • 1COBE Cardiovascular, Inc., Arvada, CO 80004, USA.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Laparoscopic preperitoneal repair for primary falciform ligament herniation.

Annals of the Royal College of Surgeons of England·2020
Same author

The Impact of the Shallow-Trench Isolation Effect on Flicker Noise of Source Follower MOSFETs in a CMOS Image Sensor.

Journal of nanoscience and nanotechnology·2018
Same author

Cultivar identification and genetic relationship of pineapple (Ananas comosus) cultivars using SSR markers.

Genetics and molecular research : GMR·2015
Same author

Inguinal Hernia: Recurrences, Tailored Surgery & Pubic Inguinal Pain Syndrome (Sportsman Hernia).

Hernia : the journal of hernias and abdominal wall surgery·2015
Same author

Molecular characterization of twenty polymorphic microsatellite markers in the polyploid fruit tree species Syzygium samarangense (Myrtaceae).

Genetics and molecular research : GMR·2015
Same author

Sister Mary Joseph nodule.

QJM : monthly journal of the Association of Physicians·2015
Same journal

Machine Learning Prediction of Pediatric In-Hospital Survival Before Extracorporeal Membrane Oxygenation Cannulation.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Erratum: Safety and Efficacy of Stored Wet-Preprimed Extracorporeal Membrane Oxygenation Circuits: A Scoping Review.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Case Series of Extracorporeal Cardiopulmonary Resuscitation for Refractory Cardiopulmonary Arrest After Cardiac Surgery.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Association Between Veno-Venous Extracorporeal Membrane Oxygenation and Right Ventricular Dysfunction in Acute Respiratory Distress Syndrome Patients: A Multicenter Retrospective Propensity-Matched Study.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Prolonged Mechanical Circulatory Support of Neonatal Biventricular Failure via Single Ventricle Conversion With Ventricular Assist Device.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Redefining Limits: Extracorporeal Cardiopulmonary Resuscitation in Adult Thrombotic Thrombocytopenic Purpura.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
See all related articles

Surface modifying additives (SMAs) improve blood compatibility in medical devices. These copolymers migrate to surfaces, reducing adverse reactions like coagulation and complement activation for safer extracorporeal circulation.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Medical Device Technology

Background:

  • Surface modifying additives (SMAs) are crucial for enhancing the biocompatibility of medical devices.
  • Polar-nonpolar block copolymers migrate to polymer surfaces, altering critical biocompatibility regions.
  • Previous applications show improved blood compatibility in cardiopulmonary bypass and hemodialysis components using SMAs.

Purpose of the Study:

  • To investigate the impact of polycaprolactone-polydimethylsiloxane-polycaprolactone triblock copolymers as SMAs on blood compatibility.
  • To characterize SMA migration and surface saturation in blended polymers.
  • To evaluate the in vitro and ex vivo blood response to SMA-modified surfaces.

Main Methods:

  • Characterization of SMAs using X-ray fluorescence (XRF), Fourier Transform Infrared (FTIR), refractive increments (RI), and gel permeation chromatography (GPC).

Related Experiment Videos

  • Surface analysis using Electron Spectroscopy for Chemical Analysis (ESCA) to confirm SMA saturation.
  • In vitro blood studies assessing contact activation, coagulation, complement, and mononuclear cell activation.
  • Ex vivo canine arteriovenous (AV) shunt studies to evaluate platelet compatibility.

    • Main Results:

    • ESCA confirmed high surface saturation of polymers with SMAs.
    • In vitro tests showed SMA polymers delayed contact activation and reduced coagulation (thrombin-antithrombin generation).
    • No adverse effects on complement (terminal complement complex generation) or mononuclear cell activation (IL-1 beta production) were observed; ex vivo studies confirmed improved platelet compatibility.

    Conclusions:

    • SMA blended polymers significantly enhance blood compatibility by reducing protein and cellular activation.
    • These findings suggest potential for reduced morbidity in patients undergoing extracorporeal circulation.
    • Polycaprolactone-polydimethylsiloxane-polycaprolactone triblock copolymers are effective SMAs for improving blood-contacting medical device performance.