Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A dynamic intravascular artificial lung

A J Makarewicz1, L F Mockros, R W Anderson

  • 1Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

Physical review letters·2024
Same author

Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment.

Physical review letters·2022
Same author

A novel method for calculating beta band burst durations in Parkinson's disease using a physiological baseline.

Journal of neuroscience methods·2020
Same author

Polarization conserving light bending prisms and optimized fresnel rhombs.

Applied optics·2010
Same author

Microchannel technologies for artificial lungs: (1) theory.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2008
Same author

Microchannel technologies for artificial lungs: (2) screen-filled wide rectangular channels.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2008
Same journal

Machine Learning Prediction of Pediatric In-Hospital Survival Before Extracorporeal Membrane Oxygenation Cannulation.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Erratum: Safety and Efficacy of Stored Wet-Preprimed Extracorporeal Membrane Oxygenation Circuits: A Scoping Review.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Case Series of Extracorporeal Cardiopulmonary Resuscitation for Refractory Cardiopulmonary Arrest After Cardiac Surgery.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Association Between Veno-Venous Extracorporeal Membrane Oxygenation and Right Ventricular Dysfunction in Acute Respiratory Distress Syndrome Patients: A Multicenter Retrospective Propensity-Matched Study.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Prolonged Mechanical Circulatory Support of Neonatal Biventricular Failure via Single Ventricle Conversion With Ventricular Assist Device.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Redefining Limits: Extracorporeal Cardiopulmonary Resuscitation in Adult Thrombotic Thrombocytopenic Purpura.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
See all related articles

Rotating fiber sheets in intravascular lung assist devices (ILADs) significantly enhance oxygen and carbon dioxide transfer. This technology improves gas exchange efficiency and reduces blood flow resistance for potential therapeutic applications.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Devices
  • Respiratory Support

Background:

  • Intravascular lung assist devices (ILADs) require efficient gas transfer (O2 and CO2) within limited surface areas.
  • Passive ILADs often fail to achieve sufficient gas transfer rates due to space constraints.
  • Active methods are needed to augment gas transfer and minimize flow resistance in ILADs.

Purpose of the Study:

  • To develop and prototype intravascular devices that enhance gas transfer and minimize blood flow resistance.
  • To investigate the principles of high-speed rotation/oscillation of fiber sheets for improved ILAD performance.
  • To create ILAD prototypes suitable for implantation within the vena cava.

Main Methods:

  • Developed novel intravascular lung assist device (ILAD) prototypes utilizing rotating or oscillating fiber sheets.

Related Experiment Videos

  • Configured fiber sheets to optimize gas transfer augmentation and reduce blood flow resistance.
  • Tested prototype performance with varying transfer surface areas (0.1 m2 to 0.5 m2).

    • Main Results:

    • Achieved significant increases in gas transfer rates, up to 800% compared to stationary devices.
    • Demonstrated reduced resistance to blood flow across the rotating fiber sheet configurations.
    • Attained O2 transfer rates up to 53 ml/min and CO2 transfer rates up to 51 ml/min.

    Conclusions:

    • High-speed rotation/oscillation of fiber sheets is an effective strategy for enhancing ILAD gas transfer.
    • Judicious fiber sheet configuration can simultaneously improve gas exchange and minimize hemodynamic resistance.
    • Developed ILAD prototypes show promise for efficient gas exchange within the vena cava.