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Ventricular interaction in the pathologic heart. A model based study

M J Moulton1, L L Creswell, S W Downing

  • 1Department of Surgery, Washington University, St. Louis, Missouri, USA.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|July 1, 1994
PubMed
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Ventricular interaction significantly impacts the left ventricle (LV) diastolic function, especially under increased right ventricular (RV) pressure. Pericardial effects and RV pressure become dominant factors influencing LV pressure-area relationships in various cardiac conditions.

Area of Science:

  • Cardiovascular Physiology
  • Biomechanical Modeling
  • Computational Cardiology

Background:

  • Ventricular interaction influences diastolic function.
  • Pathologic conditions alter cardiac mechanics.

Purpose of the Study:

  • Quantify direct and pericardially mediated ventricular interactions on diastolic left ventricle (LV) function.
  • Assess the impact of increased right ventricular (RV) pressure on LV mechanical state across various cardiac pathologies.

Main Methods:

  • Developed 2D mathematical models for normal and four pathologic LV conditions (dilated cardiomyopathy, LV hypertrophy, chronic anterior-apical infarction in normal and dilated LV).
  • Systematically increased RV pressure to evaluate changes in LV diastolic pressure-area relationships, LV free wall, and septal stresses and strains.

Related Experiment Videos

  • Incorporated pericardial effects into the models.

    • Main Results:

    • At higher RV pressures, LV pressure-area relationships became similar across all models, indicating RV and pericardial pressures are dominant factors.
    • Significant differences were observed in LV free wall and septal stress and strain changes among models following RV pressure increases.
    • Pericardial effects play a crucial role in mediating ventricular interaction.

    Conclusions:

    • RV pressure and pericardial effects are critical determinants of LV diastolic pressure-area relationships, particularly at elevated RV pressures.
    • Ventricular interaction models can predict mechanical changes in clinical conditions.
    • Understanding these interactions is vital for managing heart failure and other cardiac diseases.