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Related Experiment Videos

Time course of acetazolamide effect in normal persons

G F Hamann1, M Stoll, V Jost

  • 1Department of Neurology, University of the Saarland, Homburg/Saar, Germany.

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
|January 1, 1996
PubMed
Summary

The acetazolamide test measures cerebrovascular reserve capacity by monitoring middle cerebral artery blood flow velocity. The integral of mean flow velocity (MFV) over time best describes the drug

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Area of Science:

  • Neurology
  • Vascular Medicine
  • Pharmacology

Background:

  • Acetazolamide, a carbonic anhydrase inhibitor, increases middle cerebral artery blood flow velocity.
  • This effect is utilized in the acetazolamide test to assess cerebrovascular reserve capacity.
  • Current testing involves two-point measurements of blood flow velocity.

Purpose of the Study:

  • To develop parameters for analyzing the time course of acetazolamide's effect on cerebral blood flow.
  • To determine if time-course analysis offers a more sensitive detection of impaired cerebrovascular reserve capacity.
  • To establish normal values for these new parameters in healthy individuals.

Main Methods:

  • Intravenous injection of acetazolamide in 18 healthy individuals (31 hemispheres).

Related Experiment Videos

  • Continuous transcranial Doppler measurement of mean flow velocity (MFV).
  • Development and calculation of parameters describing the MFV time course, including maximal increase, time to maximum, rate of rise, mean change, and MFV integral.

    • Main Results:

    • The mean maximal MFV increase was 29.7 cm/sec (62.0%).
    • The mean time to maximal MFV increase was 15.35 seconds.
    • The integral of MFV over time was identified as the most effective parameter for describing the acetazolamide effect's time dependency.

    Conclusions:

    • The integral of mean flow velocity (MFV) is the optimal parameter for characterizing the time-dependent response to acetazolamide.
    • Analyzing the MFV time course may provide a more sensitive assessment of cerebrovascular reserve capacity.
    • Established normal values for MFV integral can aid in clinical interpretation.