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Adrenergic ligands trigger intracellular differentiation of trypanosoma cruzi
J E Zavala-Castro1, E Guzmán-Marín, J Zavala-Velázquez
1Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán, Mérida, Yucatán, México.
Archives of Medical Research
|January 1, 1995
Abstract:
Intracellular forms of trypanosoma cruzi, amastigote, could remain in the inner space of mammalian cells for long periods of time and be in contact with various cellular metabolism products. Some of these metabolites could act as signals that trigger parasite differentiation process to trypomastigote form. The present results suggest that increase of intracellular cAMP by adrenergic ligands or cholera toxin in parasite infected cells is able to induce such differentiation process.