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Related Experiment Videos

Changes in blood pressure control in aged rats

A Werner1, N R Rosa, A R Oliveira

  • 1Departamento de Fisiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|May 1, 1995
PubMed
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Aging impairs the baroreflex response to falling blood pressure in rats. Aged rats showed a reduced heart rate increase when blood pressure dropped, indicating compromised autonomic function.

Area of Science:

  • Cardiovascular Physiology
  • Autonomic Nervous System Function
  • Gerontology

Background:

  • The aging process involves complex changes in cardiovascular, metabolic, and autonomic functions.
  • Existing research on age-related alterations in arterial pressure, baroreflex sensitivity, glucose, and insulin levels is often contradictory.
  • Understanding these age-associated physiological shifts is crucial for geriatric health research.

Purpose of the Study:

  • To investigate age-related changes in arterial pressure (AP).
  • To assess baroreflex sensitivity in young versus aged male Wistar rats.
  • To examine variations in plasma glucose and insulin levels with aging.

Main Methods:

  • Beat-to-beat analysis of arterial pressure pulses using microcomputer processing.

Related Experiment Videos

  • Baroreflex sensitivity evaluation via heart rate changes induced by pharmacological AP manipulation (phenylephrine and sodium nitroprusside).
  • Quantification of plasma glucose and insulin using colorimetric enzymatic assay and radioimmunoassay, respectively.

    • Main Results:

    • No significant differences were observed in systolic, diastolic, or mean arterial pressure between young and aged rats.
    • The tachycardic response to a decrease in AP was significantly impaired in aged rats compared to young rats.
    • Basal plasma glucose and insulin levels were elevated in aged rats compared to their younger counterparts.

    Conclusions:

    • The reflex tachycardia response to a drop in arterial pressure is depressed in aged rats, suggesting impaired autonomic regulation.
    • Aging affects baroreflex sensitivity, specifically the sympathetic response to hypotension.
    • Distinct basal metabolic profiles (glucose and insulin) exist between young and aged rats.