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The mast cell revisited

I Mota1

  • 1Laboratório de Imunopatologia, Instituto Butantan, São Paulo, Brasil.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|August 1, 1995
PubMed
Summary

Mast cells play a dual role in allergic reactions, mediating both acute and late phases. They release histamine and leukotrienes initially, followed by pro-inflammatory cytokines.

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Mast cells are key players in allergic responses.
  • Understanding their origin, distribution, and properties is crucial.

Purpose of the Study:

  • To review the multifaceted role of mast cells in allergic reactions.
  • To detail mast cell populations, IgE receptor function, and mediator release.

Main Methods:

  • Literature review on mast cell biology and allergic mechanisms.
  • Analysis of IgE receptor structure and function.
  • Examination of mediator release in acute and late-phase reactions.

Main Results:

  • Two distinct mast cell populations with unique characteristics exist.
  • The IgE receptor on mast cells is critical for antigen recognition.
  • Mast cells release histamine and leukotrienes in the acute phase.
  • Pro-inflammatory cytokines are released during the late phase.

Conclusions:

  • Mast cells exhibit a dual role in allergic reactions.
  • Mediator release dictates the phase and severity of the allergic response.

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