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Related Experiment Videos

Clozapine-caused eosinophilic colitis

J W Friedberg1, F R Frankenburg, J Burk

  • 1McLean Hospital, Belmont, Massachusetts 02178, USA.

Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists
|June 1, 1995
PubMed
Summary
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Clozapine medication can cause a rare side effect of eosinophilic colitis, presenting as diarrhea and eosinophilia. This condition resolved in all patients after clozapine therapy was managed, suggesting it is a treatable side effect.

Area of Science:

  • Gastroenterology
  • Psychiatry
  • Pharmacology

Background:

  • Clozapine is an atypical antipsychotic medication used for treatment-resistant schizophrenia.
  • Gastrointestinal side effects are known but less common with clozapine therapy.

Purpose of the Study:

  • To present a series of patients experiencing diarrhea and eosinophilia during clozapine therapy.
  • To suggest a potential new syndrome: clozapine-induced eosinophilic colitis.

Main Methods:

  • Case series presentation of four patients.
  • Clinical observation of symptoms, laboratory findings (eosinophilia), and response to clozapine therapy.
  • Review of treatment course including interruption and re-initiation of clozapine.

Main Results:

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  • All four patients presented with diarrhea and concurrent eosinophilia.
  • In two patients, clozapine was temporarily interrupted and then restarted.
  • All patients ultimately tolerated clozapine therapy without recurrence of symptoms.

Conclusions:

  • A distinct syndrome of clozapine-induced eosinophilic colitis is proposed.
  • This condition appears manageable, with patients tolerating clozapine after initial management.
  • Early recognition of eosinophilia in patients on clozapine with gastrointestinal symptoms is important.