Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Zinc, hydrochlorothiazide and sexual dysfunction

S M Khedun1, T Naicker, B Maharaj

  • 1Department of Experimental and Clinical Pharmacology, University of Natal Medical School, Durban, South Africa.

The Central African Journal of Medicine
|October 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Zfp750 prevents oral adhesions and promotes temporary epithelial fusions.

bioRxiv : the preprint server for biology·2026
Same author

HIV-associated preeclampsia: evaluation of lymphangiogenesis in placental bed samples.

Histochemistry and cell biology·2025
Same author

Histopathological features in advanced abdominal pregnancies co-infected with SARS-CoV-2 and HIV-1 infections: A case evaluation.

European journal of obstetrics & gynecology and reproductive biology: X·2022
Same author

CAPRISA 018: a phase I/II clinical trial study protocol to assess the safety, acceptability, tolerability and pharmacokinetics of a sustained-release tenofovir alafenamide subdermal implant for HIV prevention in women.

BMJ open·2022
Same author

Genome-wide Gene-by-Sex Interaction Studies Identify Novel Nonsyndromic Orofacial Clefts Risk Locus.

Journal of dental research·2021
Same author

Dental Caries Severity and Nutritional Status of Nigerian Preschool Children.

JDR clinical and translational research·2021
Same journal

Cryptococcus gattii: A dilemma in diagnosis and treatment in sub-Saharan Africa an area with high HIV prevalence.

The Central African journal of medicine·2017
Same journal

Non-adherence to highly active antiretroviral therapy in children attending HIV treatment clinic at harare Children's Hospital, Zimbabwe.

The Central African journal of medicine·2017
Same journal

Knowledge, attitudes and practices of oral health professionals with regard to the hepatitis B virus in their workplace, Harare.

The Central African journal of medicine·2017
Same journal

Determinants of premature births in two central hospital Harare, Zimbabwe, 2011.

The Central African journal of medicine·2017
Same journal

Tetralogy of Fallot and HIV infection in pregnancy: A case report.

The Central African journal of medicine·2017
Same journal

Glucose tolerance study in low and normal birth weight young adults.

The Central African journal of medicine·2017
See all related articles

Hydrochlorothiazide, a hypertension drug, may cause sexual dysfunction by lowering body zinc. Zinc supplementation showed limited improvement in sexual dysfunction symptoms, suggesting a complex relationship.

Area of Science:

  • Endocrinology
  • Urology
  • Pharmacology

Background:

  • Hypertension is a common condition often treated with diuretics like hydrochlorothiazide.
  • Sexual dysfunction is a potential side effect of various medications, including those for hypertension.
  • The role of essential minerals, such as zinc, in sexual health is an area of ongoing research.

Purpose of the Study:

  • To investigate the hypothesis that hydrochlorothiazide depletes body zinc, leading to sexual dysfunction.
  • To compare serum zinc levels and sexual dysfunction incidence in hypertensive men taking hydrochlorothiazide versus normotensive controls.

Main Methods:

  • A comparative study involving 39 middle-aged hypertensive men on hydrochlorothiazide and 27 age-matched normotensive men.
  • Measurement of serum zinc and assessment of sexual dysfunction in both groups.

Related Experiment Videos

  • Intervention with zinc or magnesium supplementation in a subset of patients experiencing sexual dysfunction.

    • Main Results:

    • The hydrochlorothiazide group exhibited a significantly higher incidence of sexual dysfunction (56%) compared to the control group (11%).
    • Hydrochlorothiazide significantly decreased serum zinc levels (p < 0.05).
    • Zinc supplementation partially restored serum zinc levels and showed limited improvement in sexual dysfunction symptoms in a small number of patients.

    Conclusions:

    • Low serum zinc levels may be associated with hydrochlorothiazide-induced sexual dysfunction.
    • The definitive role of zinc in the pathogenesis of sexual dysfunction requires further investigation.
    • Hydrochlorothiazide's impact on zinc levels and subsequent sexual function remains a complex issue.