Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rocuronium bromide in the ICU: dose finding and pharmacokinetics

K S Khuenl-Brady1, H Sparr, F Pühringer

  • 1Department of Anaesthesia and Intensive Care Medicine, Leopold-Franzens-University of Innsbruck, Austria.

European Journal of Anaesthesiology. Supplement
|September 1, 1995
PubMed
Summary

Continuous rocuronium infusion improved ventilation control in ICU patients but resulted in deeper neuromuscular blockade compared to intermittent boluses. Pharmacokinetics in ICU patients differed from surgical patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Second generation laryngeal masks : expanded indications].

Der Anaesthesist·2015
Same author

Unexpected failure of rocuronium-mediated neuromuscular blockade.

Anaesthesia·2011
Same author

Incidence and duration of residual paralysis at the end of surgery after multiple administrations of cisatracurium and rocuronium.

Anaesthesia·2006
Same author

The prognostic impact of O6-Methylguanine-DNA Methyltransferase (MGMT) promotor hypermethylation in esophageal adenocarcinoma.

International journal of cancer·2006
Same author

[Modern CT diagnosis of acute thoracic and abdominal trauma].

Der Anaesthesist·2002
Same author

[Modern CT diagnosis of acute thoracic and abdominal trauma].

Der Radiologe·2002

Area of Science:

  • Anesthesiology
  • Critical Care Medicine
  • Pharmacology

Background:

  • Neuromuscular blocking agents are essential for mechanical ventilation in intensive care units (ICUs).
  • Rocuronium is commonly used for intubation and maintaining neuromuscular blockade.
  • Different administration methods, such as intermittent boluses versus continuous infusions, may impact efficacy and safety.

Purpose of the Study:

  • To compare the efficacy and safety of intermittent boluses versus continuous infusion of rocuronium for maintaining neuromuscular blockade in mechanically ventilated ICU patients.
  • To evaluate the pharmacokinetics of rocuronium in ICU patients receiving continuous infusions.

Main Methods:

  • A prospective study involving 30 patients requiring elective mechanical ventilation in the ICU.

Related Experiment Videos

  • Patients received either intermittent boluses (n=25) or a continuous infusion (n=5) of rocuronium.
  • Neuromuscular blockade was monitored using train-of-four (TOF) stimulation, aiming for one twitch.

    • Main Results:

    • Continuous rocuronium infusion led to better control of ventilation compared to intermittent boluses.
    • Patients receiving continuous infusion experienced a more intense neuromuscular block (9.9 +/- 1.3 microgram kg-1 min-1) versus the bolus group (6.4 +/- 2.3 microgram kg-1 min-1).
    • Pharmacokinetic parameters (elimination half-time, volume of distribution, mean residence time) were significantly longer in ICU patients than in surgical patients, while plasma clearance remained similar.

    Conclusions:

    • Continuous rocuronium infusion offers improved ventilation control in ICU settings.
    • The deeper neuromuscular blockade associated with continuous infusion requires careful monitoring.
    • Rocuronium pharmacokinetics in critically ill patients differ from those in surgical patients, necessitating individualized dosing adjustments.