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Related Experiment Videos

Plasma selenium level in cancer patients

S Gupta1, R Narang, K Krishnaswami

  • 1Department of Surgery, Mahatma Gandhi Institute of Medical Sciences, Maharashtra, India.

Indian Journal of Cancer
|September 1, 1994
PubMed
Summary

Low selenium levels are linked to increased cancer risk and incidence. This study found significantly lower plasma selenium in cancer patients, particularly those with breast and gastrointestinal cancers, correlating with disease progression and recurrence.

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Area of Science:

  • Biochemistry
  • Oncology
  • Nutritional Science

Background:

  • Selenium is recognized for its potential cancer-preventive properties.
  • Previous research suggests a correlation between higher selenium levels and reduced cancer incidence and mortality.
  • The role of selenium in various cancer types and its association with disease characteristics require further investigation.

Purpose of the Study:

  • To investigate the relationship between plasma selenium levels and cancer.
  • To examine associations with cancer site, disease extent, recurrence, histopathology, anemia, and serum protein levels.

Main Methods:

  • Plasma selenium levels were measured in 100 cancer patients and compared to healthy controls.
  • Statistical analysis was performed to determine significant differences and associations.

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Main Results:

  • Cancer patients exhibited significantly lower mean plasma selenium levels (75.35 ng/ml) compared to healthy individuals (116.99 ng/ml).
  • The strongest inverse association was observed in breast and gastrointestinal tract cancers.
  • Lower selenium levels correlated with advanced disease stage and recurrence.
  • No significant associations were found with histopathological diagnosis, anemia, or hypoproteinemia.

Conclusions:

  • Plasma selenium levels are significantly lower in cancer patients, suggesting a role in cancer development or progression.
  • Selenium status may be a relevant biomarker for breast and gastrointestinal cancers.
  • Further research is warranted to elucidate selenium's precise role in cancer prevention and treatment.