Structure-antitumor activity relationship of semi-synthetic Spicamycin derivatives
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T Sakai1, H Kawai, M Kamishohara
1Pharmaceutical Research Laboratory, Kirin Brewery Co, Ltd, Gunma, Japan.
The Journal of Antibiotics
|December 1, 1995
Abstract:
New derivatives of spicamycin modified at the fatty acid moieties of the molecule were synthesized and their structure-activity relationships were examined. The antitumor activity was greatly influenced by modification of the fatty acid moieties to tetradecadienoyl or dodecadienoyl analogues exhibiting better antitumor activity against COL-1 human colon cancer xenograft than SPM VIII.