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Multiple emulsion-based systems carrying insulin: development and characterization

S Singh1, R Singh, S P Vyas

  • 1Pharmaceutics Laboratories, Department of Pharmaceutical Sciences, Sagar (M.P.), India.

Journal of Microencapsulation
|November 1, 1995
PubMed
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A novel insulin delivery system uses liquid surfactant membranes with additives to facilitate glucose transport and enhance insulin stability. This w/o/w emulsion system shows promise for improved insulin delivery applications.

Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Biomaterials Science

Background:

  • Effective insulin delivery is crucial for diabetes management.
  • Traditional insulin delivery methods face challenges in achieving optimal glycemic control.
  • Liquid surfactant membranes offer a novel approach for controlled drug release.

Purpose of the Study:

  • To develop and characterize a new insulin delivery system utilizing liquid surfactant membranes.
  • To investigate the role of various additives in facilitating glucose transport and insulin immobilization.
  • To assess the stability and insulin release profile of the developed emulsion system.

Main Methods:

  • Formulation of a water-in-oil-in-water (w/o/w) emulsion with insulin in the internal aqueous phase.

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  • Utilizing sesame and cottonseed oils as organic liquid membranes.
  • Incorporating additives like calcium stearate, lecithin, and cholesterol to aid glucose transport.
  • Employing viscosity enhancers such as cetostearyl alcohol for insulin immobilization.
  • Characterization of emulsion stability, insulin activity, and insulin efflux profile.

    • Main Results:

    • Additives successfully facilitated glucose transport across the organic membrane to the internal aqueous phase.
    • Viscosity enhancers effectively improved insulin immobilization within the organic phase.
    • Key parameters influencing emulsion stability were identified.
    • The developed system demonstrated characterized insulin activity and efflux profiles.

    Conclusions:

    • The developed liquid surfactant membrane system is a viable approach for insulin delivery.
    • Additives play a critical role in optimizing the transport and stability of insulin within the emulsion.
    • This technology holds potential for advanced diabetes management solutions.