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The effects of nisoldipine on carotid artery stiffness and left ventricular functions
1Department of Cardiology, School of Medicine, Celal Bayar University, Manisa, Turkey.
Insights
Nisoldipine treatment significantly lowered blood pressure and improved left ventricular (LV) systolic function in hypertensive patients. However, it did not affect LV diastolic function or carotid artery stiffness.
Area of Science:
- Cardiology
- Pharmacology
- Hypertension Research
Background:
- Essential hypertension is a major risk factor for cardiovascular disease.
- Left ventricular (LV) function and arterial stiffness are key indicators of cardiovascular health.
- Nisoldipine is a calcium channel blocker used to treat hypertension.
Purpose of the Study:
- To evaluate the effects of short-term nisoldipine treatment on LV systolic and diastolic function, and carotid artery stiffness in patients with essential hypertension.
- To assess changes in cardiac output and carotid artery pulse wave velocity.
Main Methods:
- Doppler echocardiography was used to measure LV fractional shortening (FS), cardiac output (CO), and E/A ratio.
- Carotid artery pulse wave velocity and stiffness were assessed.
- Measurements were taken before and after nisoldipine treatment in 36 hypertensive patients.
Main Results:
- Blood pressure significantly decreased (p < 0.0001).
- LV fractional shortening (FS) significantly increased (p < 0.0001), indicating improved systolic function.
- Carotid artery stiffness and LV diastolic function (E/A ratio) showed no significant changes (p > 0.05).
- Carotid artery pulse wave peak velocity remained unchanged (p > 0.05).
Conclusions:
- Short-term nisoldipine administration effectively improves blood pressure and LV systolic function in essential hypertension.
- Nisoldipine does not significantly alter LV diastolic function or carotid artery stiffness.
- Nisoldipine demonstrated a favorable safety profile with minimal adverse effects.
Abstract:
Doppler echocardiographic determination, left ventricular (LV) fractional shortening (FS), cardiac output (CO), diastolic function parameter (E/A ratio) and carotid artery pulse wave velocity and stiffness were evaluated in 36 patients with essential hypertension before and after nisoldipine treatment. Blood pressure decreased significantly, and carotid artery width and fractional shortening increased significantly following nisoldipine administration (p < 0.0001). Carotid artery pulse wave peak velocity did not change following the treatment period (p > 0.05). In conclusion, short term nisoldipine administration improved blood pressure and LV systolic function, whereas LV diastolic function and carotid artery stiffness did not change. Nisoldipine did not alter serum biochemical parameters, including cholesterol, triglyceride, HDL-cholesterol, and LDL-cholesterol (p > 0.05). Only one patient manifested symptoms of hypotension as an adverse effect of the drug.