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Updated: Aug 6, 2026
Measuring Calpain Activity in Fixed and Living Cells by Flow Cytometry
Published on: July 9, 2010
A new rat model for studying the calpain-calpastatin system
L P Soldati1, B R Barber, S Salardi
1Department of Sciences and Biomedical Technologies, University of Milan, Italy.
Abstract:
A recombinant rat strain--Milan low-calpastatin strain (MLCS)--was derived from Milan hypertensive (MHS/Gib) and Milan normotensive (MNS/Gib) strains. The MLCS rats have normal blood pressure and low calpastatin activity, and this strain is proposed as a model for studies of the calpain-calpastatin system, which is involved in important cellular mechanisms. Calpastatin polymorphism was observed in 10 different strains of laboratory rats and a single locus hypothesis is suggested as the mode of inheritance.
