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Related Experiment Videos

A reversible posterior leukoencephalopathy syndrome

J Hinchey1, C Chaves, B Appignani

  • 1Department of Neurology, New England Medical Center, Boston, MA 02111, USA.

The New England Journal of Medicine
|February 22, 1996
PubMed
Summary

Posterior reversible encephalopathy syndrome is a reversible neurological condition associated with hypertension, renal disease, or immunosuppression. Prompt treatment leads to complete recovery of neurological deficits.

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Area of Science:

  • Neurology
  • Nephrology
  • Immunology

Background:

  • Posterior reversible encephalopathy syndrome (PRES) is a neurological condition characterized by headache, altered mental status, seizures, and visual disturbances.
  • Imaging studies often reveal white-matter abnormalities, predominantly in the posterior regions of the brain.

Purpose of the Study:

  • To investigate the clinical characteristics and neuroimaging findings of PRES.
  • To identify patient populations at risk for developing PRES.

Main Methods:

  • A retrospective review of 15 patients diagnosed with PRES between 1988 and 1994 was conducted.
  • Computed tomography (CT) and magnetic resonance imaging (MRI) data were analyzed.

Main Results:

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  • Common causes included immunosuppressive therapy, eclampsia, and hypertensive encephalopathy secondary to renal disease.
  • Hypertension and renal impairment were frequently observed in affected patients.
  • Neurological deficits, including visual abnormalities and seizures, resolved within two weeks of treatment.

    • Conclusions:

    • PRES is a reversible neurological disorder associated with conditions such as renal insufficiency, hypertension, and immunosuppression.
    • Neuroimaging findings are consistent with subcortical edema without evidence of infarction.