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Related Experiment Videos

Plasmapheresis in Rasmussen's encephalitis

P I Andrews1, M A Dichter, S F Berkovic

  • 1Department of Pediatrics, Duke university Medical Center, Durham, NC 27710, USA.

Neurology
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

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Rasmussen's encephalitis (RE) treatment with plasmapheresis showed promising results. Three of four patients experienced significant seizure reduction and improved neurological function, suggesting an autoimmune basis for RE.

Area of Science:

  • Neurology
  • Immunology

Background:

  • Rasmussen's encephalitis (RE) is a rare, progressive childhood neurological disorder.
  • It involves intractable focal seizures, hemiplegia, and cognitive decline, typically affecting one cerebral hemisphere.
  • Inflammatory histopathology is a key characteristic of the disease.

Purpose of the Study:

  • To investigate the efficacy of plasmapheresis in treating Rasmussen's encephalitis.
  • To explore the potential autoimmune etiology of RE.

Main Methods:

  • Four patients with pathologically confirmed Rasmussen's encephalitis were treated with repeated plasmapheresis.
  • Clinical responses were assessed by seizure frequency and neurological function.

Main Results:

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  • Three out of four patients showed dramatic, transient improvements in seizure control and neurological function after plasmapheresis.
  • One patient had only marginal improvement with the treatment.
  • These findings suggest the presence of pathogenic circulating factors, likely autoantibodies.

    • Conclusions:

    • Circulating factors, potentially autoantibodies, play a pathogenic role in some Rasmussen's encephalitis cases.
    • RE may be an autoimmune disorder.
    • Plasmapheresis can be a valuable adjunctive therapy for managing RE, including status epilepticus and pre-surgical assessment.