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Risk factors for neonatal sepsis
M K Yancey1, P Duff, P Kubilis
1Department of Obstetrics and Gynecology, Tripler Army Medical Center, Hawaii, USA.
Obstetrics and Gynecology
|February 1, 1996
Summary
Maternal infections like chorioamnionitis and group B streptococcal colonization, preterm delivery, and prolonged internal monitoring are key risk factors for neonatal sepsis. These findings aid in identifying high-risk pregnancies and improving infant outcomes.
Area of Science:
- Obstetrics and Gynecology
- Neonatal Medicine
- Infectious Diseases
Background:
- Neonatal sepsis is a significant cause of infant morbidity and mortality.
- Identifying maternal and intrapartum risk factors is crucial for prevention and early intervention.
Purpose of the Study:
- To investigate the associations between maternal characteristics, intrapartum events, and the development of neonatal sepsis.
- To identify independent risk factors for neonatal sepsis using multivariate analysis.
Main Methods:
- A cohort of 823 high-risk women was analyzed.
- Maternal and neonatal data were assessed using univariate and multivariate logistic regression models.
Main Results:
- Significant risk factors for proven neonatal sepsis included decreasing gestational age, maternal group B streptococcal infection, chorioamnionitis, endometritis, and internal monitoring exceeding 12 hours.
- Odds ratios indicated strong associations for prolonged monitoring (OR 7.2), endometritis (OR 6.4), chorioamnionitis (OR 4.4), and group B streptococcal infection (OR 4.2).
Conclusions:
- Chorioamnionitis, endometritis, preterm delivery, group B streptococcal colonization, and prolonged internal monitoring are independent risk factors for neonatal sepsis.
- The study suggests that foreign bodies traversing the birth canal may contribute to ascending peripartal infections.