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Related Experiment Videos

Elevated second-trimester maternal serum hCG alone or in combination with elevated alpha-fetoprotein

P A Benn1, D Horne, S Briganti

  • 1Department of Pediatrics, University of Connecticut Health Center, Farmington, USA.

Obstetrics and Gynecology
|February 1, 1996
PubMed
Summary

Elevated second-trimester human chorionic gonadotropin (hCG) in chromosomally normal pregnancies indicates a higher risk for adverse outcomes. Combining hCG with alpha-fetoprotein screening can improve identification of high-risk pregnancies.

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Area of Science:

  • Maternal-Fetal Medicine
  • Prenatal Screening
  • Reproductive Endocrinology

Background:

  • Second-trimester maternal serum screening is crucial for assessing fetal risk.
  • Human chorionic gonadotropin (hCG) is a key marker in prenatal diagnostics.
  • Elevated hCG can indicate various pregnancy complications.

Purpose of the Study:

  • To determine the clinical significance of elevated second-trimester maternal serum hCG.
  • To evaluate the association between high hCG levels and adverse pregnancy outcomes in chromosomally normal singleton pregnancies.
  • To assess the predictive value of hCG in conjunction with other screening markers.

Main Methods:

  • Retrospective review of 25,438 second-trimester maternal serum screening results.
  • Identification of women with hCG levels >3.0 multiples of the median (MoM).

Related Experiment Videos

  • Comparison of adverse outcomes (fetal/neonatal loss, preterm birth, small for gestational age, preeclampsia) between elevated hCG group and controls.

    • Main Results:

    • 1.3% of women had hCG levels >3.0 MoM.
    • Elevated hCG was significantly associated with increased fetal/neonatal death, preterm birth (<37 weeks, many <34 weeks), low birth weight, and preeclampsia.
    • Logistic regression identified hCG, alpha-fetoprotein, and race as independent predictors of adverse outcomes.

    Conclusions:

    • Elevated second-trimester hCG, similar to elevated alpha-fetoprotein, is linked to poor pregnancy outcomes.
    • Combined screening of hCG and alpha-fetoprotein may enhance the identification of high-risk pregnancies.
    • Early identification of high-risk pregnancies allows for timely intervention and improved management.