Related Experiment Video
Updated: Aug 8, 2026

Ovariectomy and 17β-estradiol Replacement in Rats and Mice: A Visual Demonstration
Published on: June 7, 2012
Menopause and hormone replacement therapy: an overview
1Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA.
Abstract:
This article presents an overview of the health changes that women face as they traverse menopause and the years beyond. It serves to link a series of individual articles, which follow it in this journal issue and relate to specific topics in these areas important to women's health. Indications, contraindications, and risks and benefits of hormone replacement therapy are reviewed in depth. Alternative therapies are discussed and the role of preventive health is stressed. It seems that the menopause can be a time of positive change for women, provided that they and their physicians understand and individualize their care. If there is a central theme to such management, it is the education and responsibility of both the patient and physician.
More Related Videos
Related Concept Videos
Hormonal Regulation
Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
Hormonal Control of the Ovarian Cycle
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Menopause
Major Hormones and Their Functions
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and lactation.
Hypothyroidism II: Pathophysiology

