Related Experiment Videos
Central insulin enhances sensitivity to cholecystokinin
C A Riedy1, M Chavez, D P Figlewicz
1Department of Psychology, University of Washington, Seattle 98195, USA.
Physiology & Behavior
|October 1, 1995
Summary
Central insulin enhances the appetite-suppressing effects of cholecystokinin (CCK) in rats. This suggests insulin may modulate sensitivity to satiety signals, impacting food intake and body weight regulation.
Area of Science:
- Neuroscience
- Endocrinology
- Behavioral Science
Background:
- Insulin, acting centrally, reduces food intake and body weight.
- Cholecystokinin (CCK), administered peripherally, decreases meal size.
Purpose of the Study:
- To investigate the interaction between central insulin and peripheral CCK on feeding behavior.
- To determine if central insulin influences sensitivity to CCK's anorexic effects.
Main Methods:
- Rats received intracerebroventricular insulin or saline infusions.
- Subsequent experiments involved acute injections of insulin and intraperitoneal CCK-8.
- Feeding behavior, meal size, and body weight were monitored.
Main Results:
- Central insulin alone did not affect body weight or meal size.
- Insulin administration potentiated the anorexic effect of CCK-8.
- Results were consistent across different experimental designs, despite initial interpretation challenges.
Conclusions:
- Central insulin enhances the satiety effects of CCK.
- Insulin may act by altering the brain's sensitivity to peripheral satiety signals.
- This interaction could be a key mechanism in regulating food intake and body weight.