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Related Experiment Videos

[Native valve endocarditis caused by Staphylococcus aureus and streptococci. A comparative study]

J A Cartón1, J A Maradona, V Asensi Alvarez

  • 1Servicio de Medicina Interna, Enfermedades Infecciosas, Hospital Central de Asturias.

Revista Clinica Espanola
|November 1, 1995
PubMed
Summary
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Clinical prototypes for streptococcal endocarditis (STREPEND) and Staphylococcus aureus endocarditis (SAE) remain valid. Differentiating nosocomial infections and considering aggressive surgery for left-sided Staphylococcus aureus endocarditis are crucial.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Clinical Microbiology

Background:

  • Endocarditis remains a significant clinical challenge with distinct etiological profiles.
  • Understanding the current validity and prognosis of streptococcal endocarditis (STREPEND) and Staphylococcus aureus endocarditis (SAE) is essential for effective management.
  • Traditional classifications of endocarditis etiologies require ongoing validation in contemporary clinical practice.

Purpose of the Study:

  • To evaluate the current validity and prognosis of clinical prototypes for STREPEND and SAE.
  • To compare patient cohorts diagnosed with SAE and STREPEND.
  • To identify independent predictors of mortality and clinical outcomes for each endocarditis type.

Main Methods:

  • Retrospective cohort study design comparing 54 patients with SAE and 43 patients with STREPEND.

Related Experiment Videos

  • Data collected for patients diagnosed between 1984 and 1994.
  • Multivariant analysis employed to identify independent associations with clinical outcomes.

    • Main Results:

    • SAE incidence was 0.21 and STREPEND incidence was 0.17 per 1,000 hospital admissions.
    • SAE was predominantly community-acquired in non-drug abusers (31%) and drug abusers (43%), with 26% nosocomial.
    • STREPEND was predominantly community-acquired in non-drug abusers (70%) and drug abusers (19%), with 11% nosocomial. Overall mortality: STREPEND 9%, SAE 26%.
    • SAE independently associated with drug abuse, right-sided infection, embolism, and high mortality.
    • STREPEND independently associated with subacute onset, left-sided infection, cardiac surgery, and low mortality.

    Conclusions:

    • The traditional etiological stereotypes for STREPEND and SAE remain valid.
    • Differentiating nosocomial endocarditis and endocarditis in non-drug abusers is clinically important.
    • Low chemoprophylaxis compliance for STREPEND and the poor prognosis of left-sided SAE warrant consideration for more aggressive surgical intervention.