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Decreased plasma tissue factor pathway inhibitor activity in ischemic stroke patients
T Abumiya1, T Yamaguchi, T Terasaki
1Research Institute, National Cardiovascular Center, Osaka, Japan.
Thrombosis and Haemostasis
|October 1, 1995
Summary
Tissue factor pathway inhibitor (TFPI) activity is lower in ischemic stroke patients compared to controls. This reduction, particularly in atherothrombotic and lacunar infarction, may stem from atherosclerosis rather than blood consumption.
Area of Science:
- Biochemistry
- Hematology
- Vascular Biology
Background:
- Tissue factor pathway inhibitor (TFPI) is crucial for regulating blood coagulation.
- Quantitative changes in TFPI levels during thrombotic diseases remain unclear.
Purpose of the Study:
- To investigate TFPI activity in patients with ischemic stroke.
- To compare TFPI levels between stroke patients and age- and cholesterol-matched controls.
Main Methods:
- Measurement of TFPI activity in plasma samples from ischemic stroke patients and healthy controls.
- Comparison of TFPI activity across different ischemic stroke subtypes (atherothrombotic, lacunar, cardioembolic).
Main Results:
- Significantly lower TFPI activity was observed in ischemic stroke patients (1.01 U/ml) versus controls (1.10 U/ml).
- TFPI activity was notably reduced in atherothrombotic (0.93 U/ml) and lacunar (0.99 U/ml) infarction subtypes.
- No significant difference in TFPI activity was found for cardioembolic infarction.
- No correlation was found between TFPI activity and markers of thrombin/fibrin production or fibrinolysis.
Conclusions:
- Moderately reduced TFPI activity in stroke patients may be linked to underlying atherosclerotic processes.
- The findings suggest TFPI levels are not significantly depleted due to consumptive coagulopathy in ischemic stroke.