Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HLA phenotypes and severe Rh(D) immunization

J O Hildén1, T Gottvall, B Lindblom

  • 1Department of Transfusion Medicine & Clinical Immunology, University Hospital, Linköping, Sweden.

Tissue Antigens
|October 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intervention during pregnancy to reduce excessive gestational weight gain—a randomised controlled trial.

BJOG : an international journal of obstetrics and gynaecology·2014
Same author

Autosomal SNP typing of forensic samples with the GenPlex™ HID System: results of a collaborative study.

Forensic science international. Genetics·2010
Same author

High frequency of occurrence of CYP2D6 gene duplication/multiduplication indicating ultrarapid metabolism among suicide cases.

Clinical pharmacology and therapeutics·2009
Same author

Incidence of severe reproductive tract complications associated with diagnosed genital chlamydial infection: the Uppsala Women's Cohort Study.

Sexually transmitted infections·2006
Same author

Fatal intoxication cases: cytochrome P450 2D6 and 2C19 genotype distributions.

European journal of clinical pharmacology·2004
Same author

The concentration of nitrite in seminal plasma does not correlate with sperm concentration, sperm motility, leukocytospermia, or sperm culture.

Fertility and sterility·2001
Same journal

Corrigendum.

Tissue antigens·2015
Same journal

Nomenclature for factors of the HLA system, update September 2015.

Tissue antigens·2015
Same journal

Nomenclature for factors of the HLA system, update August 2015.

Tissue antigens·2015
Same journal

Nomenclature for factors of the HLA system, update July 2015.

Tissue antigens·2015
Same journal

Four amino acid exchanges located in the alpha-2 domain specify the novel HLA-B*50:20 allele.

Tissue antigens·2015
Same journal

A novel HLA-A*02 variant, HLA-A*02:575, detected in a Taiwanese bone marrow hematopoietic stem cell donor.

Tissue antigens·2015
See all related articles

Severe Rh(D) immunization in pregnant women is linked to the HLA-DQB1*0201 allele. This genetic marker may help predict the risk of hemolytic disease of the newborn, enabling early intervention.

Area of Science:

  • Immunogenetics
  • Maternal-fetal medicine
  • Transfusion medicine

Background:

  • Rh(D) immunization can lead to hemolytic disease of the newborn (HDN).
  • Predicting the severity of HDN is crucial for timely intervention.
  • Human Leukocyte Antigen (HLA) polymorphisms are associated with immune responses.

Purpose of the Study:

  • To investigate the correlation between HLA-DQB1 polymorphisms and the severity of Rh(D) immunization in women.
  • To assess the potential of HLA phenotyping for predicting severe HDN.

Main Methods:

  • Analysis of blood samples from 24 Rh(D) immunized women.
  • Quantification of anti-D antibody titers.
  • Identification of HLA-DR and -DQ polymorphisms using Restriction Fragment Length Polymorphism (RFLP).

Related Experiment Videos

Main Results:

  • The HLA-DQB1*0201 allele was found in 18% of women with moderate anti-D titers (16-256).
  • In women with high anti-D titers (> or = 512), the HLA-DQB1*0201 allele was present in 85%.
  • Severe fetal complications and frequent need for in-utero treatment were observed in the high-titer group associated with HLA-DQB1*0201.

Conclusions:

  • A strong correlation exists between severe Rh(D) immunization and the presence of the HLA-DQB1*0201 allele.
  • HLA phenotyping of women with early anti-D antibodies can predict the risk of severe HDN.
  • This approach may facilitate proactive management of Rh(D) alloimmunization.