Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hodgkin's disease after transplantation

J L Garnier1, Y Lebranchu, J Dantal

  • 1Inserm U80, Service d'Urologie, Département d' Hématologie, Hôpital Edouard Herriot, Lyon, France.

Transplantation
|January 15, 1996
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Comprehensive DNA Barcode Reference Library for the Macroinvertebrates of Scottish Seagrass Beds Using Oxford Nanopore Flongle Flowcells.

Ecology and evolution·2025
Same author

Arrhythmogenic cardiomyopathy as a myogenic disease: highlights from cardiomyocytes derived from human induced pluripotent stem cells.

Frontiers in physiology·2023
Same author

Ablating Ion Velocity Distributions in Short-Pulse-Heated Solids via X-Ray Doppler Shifts.

Physical review letters·2022
Same author

Clinical considerations for DPD deficiency testing in advanced cancer patients: tumor lysis syndrome should be considered as a major interference.

Annals of oncology : official journal of the European Society for Medical Oncology·2022
Same author

Resonant dielectric multilayer with controlled absorption for enhanced total internal reflection fluorescence microscopy.

Optics express·2022
Same author

Vacuum laser acceleration of super-ponderomotive electrons using relativistic transparency injection.

Nature communications·2022

This study reports on seven transplant recipients who developed Hodgkin's disease (HD), finding Epstein-Barr virus (EBV) in all cases. Treatment outcomes suggest a link between EBV, immunosuppression, and HD progression post-transplant.

Area of Science:

  • Oncology
  • Virology
  • Transplantation Immunology

Background:

  • Hodgkin's disease (HD) is rarely reported after organ transplantation.
  • Epstein-Barr virus (EBV) is implicated in HD pathogenesis, particularly in immunocompromised individuals.

Purpose of the Study:

  • To investigate the clinical and pathological features of HD in transplant recipients.
  • To determine the role of Epstein-Barr virus (EBV) in post-transplant HD.
  • To analyze treatment outcomes and prognostic factors for HD in this population.

Main Methods:

  • Retrospective analysis of 7 transplant recipients diagnosed with HD.
  • Clinical and pathological data review, including staging and histological subtyping.
  • Immunohistochemical and in situ hybridization studies for EBV markers (LMP, EBNA2, EBERs).

Related Experiment Videos

  • Review of EBV serological data and treatment regimens.

    • Main Results:

    • HD occurred a mean of 49 months post-transplantation.
    • Mixed cellularity was the most frequent histological subtype (6/7 cases).
    • EBV was detected in all HD tumors, with Reed-Sternberg cells expressing LMP but not EBNA2.
    • Four patients experienced primary EBV infection post-transplant prior to HD diagnosis.
    • Treatment involved radiotherapy and/or chemotherapy, with immunosuppression reduction.
    • Four patients achieved complete remission, while two died from infection.

    Conclusions:

    • Post-transplant HD shares features with EBV-associated HD in other immunocompromised states.
    • EBV infection and immunosuppression likely play a significant role in the development and progression of HD after transplantation.
    • Mixed cellularity and EBV presence are characteristic of HD in transplant recipients.