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Salmonella typhi infections. A 10-year retrospective study
G Seçmeer1, G Kanra, A P Cemeroğlu
1Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
The Turkish Journal of Pediatrics
|October 1, 1995
Summary
This study on enteric fever in children found Salmonella infections are common, with increasing antimicrobial resistance posing treatment challenges. Key symptoms include neurologic findings and elevated liver enzymes.
Area of Science:
- Pediatrics
- Infectious Diseases
- Microbiology
Background:
- Enteric fever remains a significant global health concern, particularly affecting pediatric populations.
- Clinical and laboratory features, alongside antimicrobial resistance patterns, are crucial for effective management.
Purpose of the Study:
- To retrospectively analyze the clinical and laboratory characteristics of enteric fever in children over a decade.
- To investigate the incidence and trends of antimicrobial resistance in pediatric enteric fever cases.
Main Methods:
- A ten-year retrospective study involving blood cultures from pediatric patients diagnosed with enteric fever.
- Analysis of clinical signs, laboratory findings (including blood counts and liver enzymes), and Salmonella species identification.
Main Results:
- Salmonella was isolated in 105 pediatric patients, with Salmonella typhi identified in 27 cases; most patients were over two years old.
- Neurologic findings (29.2%), elevated liver enzymes (68.5%), anemia (44%), leukopenia (16%), and leukocytosis (11.1%) were observed.
- A concerning rise in antimicrobial resistance to ampicillin, chloramphenicol, and trimethoprim-sulfamethoxazole was noted in the last five years.
Conclusions:
- Enteric fever presents with diverse clinical and laboratory manifestations in children, including frequent neurologic involvement and liver enzyme abnormalities.
- The increasing antimicrobial resistance to common antibiotics necessitates updated treatment guidelines and highlights the need for ongoing surveillance.