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Endoscopic intrauterine fetal therapy: a monkey model

W F Feitz¹, E A Steegers, R G Aarnink

¹Department of Urology, University Hospital Nijmegen, The Netherlands.

|January 1, 1996

Summary

Endoscopic intra-amniotic access was successfully achieved in a primate model, enabling intrauterine fetoscopy for studying genitourinary tract abnormalities. This technique shows promise for investigating prenatal developmental issues.

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Area of Science:

Reproductive biology
Surgical innovation
Primate research

Background:

Prenatal ultrasonography detects increasing urogenital tract abnormalities.
Endoscopic techniques offer potential for in-utero diagnosis and treatment.
A suitable animal model is needed to develop these techniques.

Purpose of the Study:

To evaluate the feasibility of endoscopic intra-amniotic access in a primate model.
To establish a primate model for intrauterine endoscopic surgery research.

Main Methods:

Endoscopic intrauterine fetoscopy was performed in 10 midtrimester rhesus monkeys using three access cannulas.
A Seldinger technique and pediatric laparoscopy set facilitated intra-amniotic inspection.
Fetal growth was monitored via serial ultrasonographic biometry.

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Main Results:

Successful intrauterine access was achieved in all 10 monkeys.
Adequate fetoscopy was possible after amniotic fluid exchange.
No significant disturbance in fetal growth patterns was observed in the 8 surviving monkeys.

Conclusions:

The rhesus monkey is a suitable model for experimental intrauterine endoscopic surgery.
This model can be used to study developmental abnormalities of the genitourinary tract.
Further research can advance minimally invasive prenatal interventions.