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Swine dysentery: more unknown than known
1Department of Bacteriology, Faculty of Veterinary Medicine, University of Utrecht, Netherlands.
Veterinary Microbiology
|October 1, 1995
Summary
Swine dysentery (SD) control requires better diagnostics and vaccines. Research highlights the need for sensitive tests to detect carriers and understand Serpulina hyodysenteriae pathogenesis, including motility's role.
Area of Science:
- Veterinary Medicine
- Microbiology
Background:
- Swine dysentery (SD) is a significant economic disease in pigs, caused by Serpulina hyodysenteriae.
- Current control methods include hygiene and antimicrobials, but carrier detection and vaccination require further development.
Purpose of the Study:
- To review recent findings on swine dysentery pathogenesis and diagnostics.
- To identify areas for improved control strategies, including carrier exclusion and vaccine development.
Main Methods:
- Review of current literature on Serpulina hyodysenteriae.
- Analysis of diagnostic test limitations for carrier detection.
- Examination of research into SD pathogenesis and virulence factors.
Main Results:
- Existing diagnostic tests for S. hyodysenteriae carriers lack sufficient sensitivity and/or specificity.
- Hemolysin/cytotoxin are known virulence factors, with recent evidence suggesting motility also plays a role in pathogenesis.
- Further research is needed for reliable diagnostics and effective vaccine development.
Conclusions:
- Improved diagnostic sensitivity and specificity are crucial for effective swine dysentery carrier detection and exclusion.
- Understanding Serpulina hyodysenteriae pathogenesis, particularly the role of motility, is key for developing novel control strategies and vaccines.