[The correlation of dopamin- and enkephalinergic influences on rat conditioned-reflex activity]

Behavioural effects of enkephalin microinjections into substantia nigra of rat brain were studied in short time after intrastriatal administration of 6-hydroxydopamine (6-OHDA). It was shown that such microinjections improved conditioned activity of animals. A conclusion was made that the role of enkephalinergic brain structures in compensatory processes in acute period of development of 6-OHDA neurotoxic action was related to increase in efficiency of the mechanisms of self-regulation of dopamine neurons.