[Dynamics of morphofunctional changes in the fibroblasts of a focus of inflammation]

Morphometrical, histochemical and electron-microscopic methods were used in order to show that the inflammatory reactions in the traumatized connective tissue were accompanied by massive death of fibroblasts. In surviving cells the protein synthesis increased and the mitotic activity rose. The synthetic and secretory organs in fibroblasts became mostly developed by the 2--5th day. The increased synthesis of proteins was associated with the formation of the connective tissue capsule around the foreign body. As the capsule matured, the synthetic activity and the mitotic activity of fibroblasts decreased. In some cells the destruction phenomena were observed.