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[Platinum-based antineoplastic agents: biomedical applications and therapeutic aspects]
C Dominici1, F Petrucci, A Alimonti
1Clinica Pediatrica, Universià degli Studi, La Sapienza, Roma.
Annali Dell'Istituto Superiore Di Sanita
|January 1, 1995
Summary
This review summarizes recent research on platinum-based chemotherapy, focusing on cisplatin
Area of Science:
- Oncology
- Pharmacology
- Clinical Research
Context:
- Platinum-based drugs, particularly cisplatin, are crucial in cancer chemotherapy.
- Recent decade investigations cover analytical, clinical, and pharmacological data.
- Focus on solid tumors in both adult and pediatric populations.
Purpose:
- To review clinical studies evaluating therapeutic response and toxicity of cisplatin.
- To examine regional and systemic administration of cisplatin.
- To discuss concurrent therapies with hyperthermia and radiotherapy.
Summary:
- The review analyzes clinical data on cisplatin efficacy and toxicity in treating solid tumors.
- It covers both localized and widespread cancer treatments.
- Concurrent use with hyperthermia for limb tumors and radiotherapy for lung cancer is discussed.
Impact:
- Provides a comprehensive overview of cisplatin chemotherapy advancements.
- Informs clinical decision-making for cancer treatment strategies.
- Highlights the role of platinum-based drugs in oncology.