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Related Experiment Videos

How Salmonella survive against the odds

J W Foster1, M P Spector

  • 1Department of Microbiology and Immunology, College of Medicine, University of South Alabama, Mobile 36688, USA.

Annual Review of Microbiology
|January 1, 1995
PubMed
Summary

Salmonella typhimurium survives harsh conditions by employing specific and cross-protective defenses. This enteric pathogen invades host cells, manipulating signaling pathways to persist and cause infection.

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Area of Science:

  • Microbiology
  • Pathogen Survival
  • Bacterial Stress Response

Background:

  • The enteric pathogen Salmonella typhimurium encounters diverse environmental and host-induced stresses.
  • Survival requires managing conditions like nutrient fluctuations, pH changes, osmotic stress, oxidative damage, and antimicrobial peptides.

Purpose of the Study:

  • To investigate the survival strategies of Salmonella typhimurium in both environmental and host-associated conditions.
  • To understand how Salmonella typhimurium copes with simultaneous stresses within a host, particularly inside phagocytes.

Main Methods:

  • Analysis of Salmonella typhimurium's stress response mechanisms.
  • Investigation of bacterial invasion and intracellular survival strategies.
  • Examination of host-pathogen interactions and manipulation of host signaling pathways.

Main Results:

  • Salmonella typhimurium utilizes specific and cross-protective defenses to overcome environmental challenges.
  • The pathogen invades host phagocytes, evading extracellular immunity.
  • It manipulates host signal-transduction pathways to facilitate entry and survival within host cells.

Conclusions:

  • Salmonella typhimurium possesses a robust stress-response arsenal enabling survival in diverse, hostile environments.
  • Intracellular survival strategies, including host pathway manipulation, are crucial for pathogenesis.
  • These adaptations allow persistence in nature and equip the bacterium for successful infection.

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