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CO dehydrogenase

J G Ferry1

  • 1Department of Biochemistry, Microbiology, Molecular & Cell Biology, Pennsylvania State University, University Park 16802-4500, USA.

Annual Review of Microbiology
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Carbon monoxide (CO) dehydrogenases are vital enzymes in microbial energy metabolism. These diverse enzymes facilitate CO oxidation in aerobes and CO conversion in various anaerobes, supporting unique metabolic pathways.

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Area of Science:

  • Biochemistry
  • Microbiology
  • Enzymology

Background:

  • Carbon monoxide (CO) dehydrogenases are crucial enzymes in microbial energy metabolism.
  • They are found in diverse Bacteria and Archaea, participating in both aerobic and anaerobic pathways.

Purpose of the Study:

  • To elucidate the structural and functional diversity of CO dehydrogenases.
  • To understand their roles in various microbial energy-yielding pathways.

Main Methods:

  • Comparative analysis of CO dehydrogenase structures and functions.
  • Review of microbial metabolic pathways involving CO oxidation and CO2/H2/CH4 production.

Main Results:

  • Aerobic microbes use Mo-Fe-flavin CO dehydrogenases for CO oxidation.

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  • Anaerobic microbes employ nickel-iron-sulfur CO dehydrogenases for CO to H2 conversion, acetyl-CoA synthesis, and acetyl-CoA cleavage.

    • Conclusions:

    • CO dehydrogenases exhibit significant structural and functional diversity across microbial domains.
    • These enzymes are central to distinct energy-yielding strategies in both aerobic and anaerobic microorganisms.