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Eosinophil cationic protein in perennial allergic rhinitis
1Department of Otorhinolaryngology, Yamanashi Medical University, Japan.
Auris, Nasus, Larynx
|January 1, 1995
Summary
Eosinophil cationic protein (ECP) in nasal secretions is a potential marker for perennial allergic rhinitis severity. Higher ECP levels in nasal secretions correlate with allergic rhinitis symptoms, suggesting eosinophil activation in the nasal mucosa.
Area of Science:
- Immunology
- Allergology
- Otorhinolaryngology
Background:
- Perennial allergic rhinitis involves eosinophil activation.
- Eosinophil cationic protein (ECP) is a key mediator released by activated eosinophils.
Purpose of the Study:
- To quantitatively investigate eosinophil activation in perennial allergic rhinitis.
- To assess eosinophil cationic protein (ECP) concentrations in serum and nasal secretions.
- To correlate ECP levels with clinical severity and nasal eosinophilia.
Main Methods:
- Radioimmunoassay was used to measure ECP concentrations.
- ECP was measured in serum, nasal secretions (ECPWN), and nasal secretion supernatant (ECPsup).
- Measurements were taken from normal subjects and patients with perennial allergic rhinitis.
Main Results:
- ECPWN and ECPsup levels were significantly higher than ECPserum levels.
- ECPsup demonstrated a positive correlation with clinical severity of allergic rhinitis.
- No significant correlation was found between ECP levels and eosinophilia in nasal smears.
- A weak, non-significant trend suggested increased histamine sensitivity with higher ECPsup.
Conclusions:
- Results indicate eosinophil accumulation and activation within the allergic nasal mucosa.
- ECPsup emerges as a potential clinical parameter for assessing perennial allergic rhinitis.
- ECP measurement in nasal secretions may offer insights into disease activity.