Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A case against subtyping in schizophrenia

T E Goldberg1, D R Weinberger

  • 1Clinical Brain Disorders Branch, IRP, NIMH, NIH, Washington, DC 20032, USA.

Schizophrenia Research
|October 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic vulnerability to DUSP22 promoter hypermethylation is involved in the relation between in utero famine exposure and schizophrenia.

NPJ schizophrenia·2018
Same author

GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium.

Molecular psychiatry·2017
Same author

Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder.

Molecular psychiatry·2017
Same author

GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia.

Molecular psychiatry·2017
Same author

Investigating the neuroimmunogenic architecture of schizophrenia.

Molecular psychiatry·2017
Same author

Altered expression of histamine signaling genes in autism spectrum disorder.

Translational psychiatry·2017
Same journal

Quality evaluation of randomized controlled trials of antipsychotic drugs for schizophrenia published in Chinese journals.

Schizophrenia research·2026
Same journal

FL-SDGIN: A federated graph learning approach for schizophrenia diagnosis integrating static and dynamic brain functional networks.

Schizophrenia research·2026
Same journal

Weight loss and gut microbial changes associated with semaglutide among people living with schizophrenia receiving clozapine or olanzapine: An open-label 24-week semaglutide intervention and 76-week trial.

Schizophrenia research·2026
Same journal

Converting negative symptom dimension scores across SANS and PANSS.

Schizophrenia research·2026
Same journal

Inflammation-associated alterations in mGluR transcript expression in the human nucleus accumbens independent of schizophrenia diagnosis.

Schizophrenia research·2026
Same journal

One social interaction after another: Dynamic modeling of social experience in schizophrenia.

Schizophrenia research·2026
See all related articles

Schizophrenia heterogeneity is challenged by evidence suggesting neurobiological abnormalities are common across patients. A single severity dimension may better explain variations in schizophrenia, rather than distinct subtypes.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • The prevailing view posits schizophrenia as a heterogeneous disorder.
  • This heterogeneity is traditionally supported by clinical presentation, disease course, and factor analysis.

Purpose of the Study:

  • To critically evaluate the concept of schizophrenia heterogeneity.
  • To explore alternative models for understanding schizophrenia's varied presentation.

Main Methods:

  • Analysis of clinical presentation, disease course, and factor analysis data.
  • Examination of case-control studies, including discordant monozygotic twins.
  • Assessment of neurocognitive, cerebral blood flow, and neuroanatomical data distributions.

Main Results:

Related Experiment Videos

  • Internal contradictions challenge the heterogeneity model, with shifting subtypes and co-occurring symptoms.
  • Neurocognitive, cerebral blood flow, and neuroanatomical abnormalities appear prevalent in nearly all schizophrenia patients.
  • A model of a single severity dimension may explain observed variance more parsimoniously.

Conclusions:

  • Schizophrenia's heterogeneity may be an oversimplification.
  • Underlying unitary pathogenesis with varying impact could explain diverse presentations.
  • Future research should focus on identifying this core pathogenesis despite potential multiple etiologies.