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Related Experiment Videos

Optic nerve head circulation in untreated ocular hypertension

G T Feke1, B Schwartz, T Takamoto

  • 1Schepens Eye Research Institute, Boston, MA 02114, USA.

The British Journal of Ophthalmology
|December 1, 1995
PubMed
Summary

Ocular hypertensive patients show increased capillary blood speed in the optic nerve head compared to healthy individuals. This heightened blood flow is linked to thinner retinal nerve fiber layers, suggesting a compensatory mechanism.

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Area of Science:

  • Ophthalmology
  • Cardiovascular Research
  • Medical Imaging

Background:

  • Ocular hypertension is a risk factor for glaucoma.
  • Optic nerve head (ONH) blood flow is crucial for retinal ganglion cell survival.
  • Understanding ONH hemodynamics in ocular hypertension is vital for early disease detection.

Purpose of the Study:

  • To compare capillary blood speed in the optic nerve head between ocular hypertensive patients and healthy controls.
  • To investigate the relationship between retinal nerve fiber layer (RNFL) thickness and blood flow in the ONH.

Main Methods:

  • Laser Doppler velocimetry was used to measure capillary blood speed at localized ONH sites.
  • Stereophotogrammetry was employed to assess RNFL thickness.
  • Measurements were taken in ocular hypertensive patients and age/sex-matched healthy subjects.

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Main Results:

  • Capillary blood speed was significantly higher in ocular hypertensive patients (p=0.018).
  • Increased blood flow correlated with thinner RNFL at adjacent ONH sites.
  • A significant inverse relationship was found between Doppler broadening and RNFL thickness in left eyes (p=0.0004).

Conclusions:

  • Stable, untreated ocular hypertensive patients exhibit spatial heterogeneity of blood flow in the optic nerve head.
  • A compensatory increase in local blood supply may occur in areas of RNFL thinning.
  • These findings suggest altered ONH hemodynamics in ocular hypertension.