Autoantibodies in hepatitis delta

Hepatitis delta virus infection is associated with a wide range of different autoantibodies. The humoral immune response in chronic hepatitis D is directed against the cytoskeleton, the nucleus, the nuclear lamina and the endoplasmic reticulum. Smooth muscle antibodies (SMA), basal cell layer antibodies (BCLA), stellate epithelial cell antibodies (SECA), thymic reticular cell antibodies (TRA), perithymocytic cell antibodies (PTA), and anti-calmodulin antibodies are reactive with constituents of the cytoskeleton. Antinuclear antibodies (ANA) and anti-lamin C antibodies recognize antigens of the nucleus and the nuclear lamina, respectively. Autoantibodies directed against antigens of the endodoplasmic reticulum (LKM) are also common in chronic hepatitis D. Recently, the major molecular target of LKM-3 autoantibodies was described as an epitope on UDP-glucuronosyltransferases of family 1. In view of the important role of UGTs in drug metabolism, LKM-3 autoantibodies represent a new model to study virus induced autoimmunity in man. Future studies should focus on the role of the host immune response and the clinical relevance of these autoantibodies in chronic hepatitis D.