Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autoantibodies in hepatitis delta

T Philipp1, P Obermayer-Straub, M P Manns

  • 1Abteilung Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover, Germany.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 1, 1995
PubMed
Summary

Chronic hepatitis D infection triggers diverse autoantibodies targeting cellular components. LKM-3 autoantibodies against UDP-glucuronosyltransferases offer a new model for studying virus-induced autoimmunity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Virological and clinical characteristics of delta hepatitis in Central Europe.

Journal of viral hepatitis·2009
Same author

Hepatitis C virus-specific T cell responses against conserved regions in recovered patients.

Vaccine·2009
Same author

Presumed cryptogenic liver disease in Germany: High prevalence of autoantibody-negative autoimmune hepatitis, low prevalence of NASH, no evidence for occult viral etiology.

Zeitschrift fur Gastroenterologie·2009
Same author

[Liver transplantation: indications and results].

Der Internist·2009
Same author

[Transplantation medicine 2009].

Der Internist·2009
Same author

Transient autoimmune hepatitis induced by a thymoma.

The American journal of gastroenterology·2009

Area of Science:

  • Immunology
  • Virology
  • Hepatology

Background:

  • Hepatitis delta virus (HDV) infection is linked to numerous autoantibodies.
  • The immune response in chronic HDV targets cytoskeleton, nucleus, nuclear lamina, and endoplasmic reticulum.

Purpose of the Study:

  • To characterize the autoantibody targets in chronic hepatitis D.
  • To investigate the role of LKM-3 autoantibodies and their target UDP-glucuronosyltransferases (UGTs).

Main Methods:

  • Analysis of humoral immune response in chronic hepatitis D patients.
  • Identification of molecular targets for autoantibodies, including LKM-3.

Main Results:

  • Autoantibodies identified include smooth muscle antibodies (SMA), antinuclear antibodies (ANA), and anti-lamin C.

Related Experiment Videos

  • LKM-3 autoantibodies target an epitope on UDP-glucuronosyltransferases family 1 (UGT1).

    • Conclusions:

    • Chronic hepatitis D induces a broad spectrum of autoantibodies.
    • LKM-3 autoantibodies against UGT1 provide a novel model for studying viral autoimmunity and its implications in drug metabolism.