Related Experiment Video
Updated: Aug 17, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
Endothelium-dependent regulation of the cardiovascular system
1Research Institute of Angiocardiology, Kyushu University School of Medicine, Fukuoka.
Abstract:
Vascular endothelial cells play an important role in modulating cardiovascular function, by liberating several vasoactive substances, such as prostacyclin, endothelium-derived relaxing factor/nitric oxide, a hyperpolarizing substance, and vasoconstrictor substances. Their roles in the cardiovascular system include modulation of the contraction of the underlying vascular smooth muscle, interaction between blood components and blood vessel wall, vascular growth, as well as regulation of the cardiovascular system at several levels beyond the vascular wall. Alterations in the endothelial functions and the related processes are now known to be involved in the pathogenesis of many cardiovascular diseases, including hypertension and atherosclerosis. Thus, the impaired endothelial regulation of the cardiovascular system may have an important implication for the development and progression of many cardiovascular diseases.
More Related Videos
08:41Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
09:47Measurement of Endothelium-Dependent Vasorelaxation in the Mouse Thoracic Aorta Using Tensometric Small Volume Chamber Myography
Published on: August 12, 2022
Related Concept Videos
Overview of the Vascular System
Regulation of Angiogenesis and Blood Supply
Hypertension and Regulation of Blood Pressure
Neural Regulation of Blood Pressure
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Autoregulation of Blood Flow
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
Regulation of the Cardiovascular System
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...