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[Coagulase-negative staphylococci in normal and chronically inflamed conjunctiva]
T Grasbon1, H Miño de Kaspar, V Klauss
1Augenklinik, Universität M nchen.
Summary
Coagulase-negative staphylococci are common in the conjunctiva, with varying antibiotic resistance. Chronic conjunctivitis increases the risk of multiresistant strains, suggesting a disrupted microbiological balance.
Area of Science:
- Ophthalmology
- Microbiology
- Infectious Diseases
Context:
- The conjunctiva harbors a diverse microbial flora, including Staphylococcus species.
- Understanding the prevalence and antibiotic susceptibility of these bacteria is crucial for managing ocular infections.
Purpose:
- To investigate the prevalence of coagulase-negative Staphylococcus species in normal and inflamed conjunctiva.
- To determine the antibiotic sensitivity of these bacterial strains.
- To explore the relationship between coagulase-negative staphylococci and other conjunctival flora.
Summary:
- Coagulase-negative staphylococci were highly prevalent (86%) in conjunctival swabs, with Staphylococcus epidermidis being the most common species.
- Antibiotic resistance varied significantly, with high rates of resistance to penicillin (66%) and lower rates to vancomycin (0%).
- Patients with chronic conjunctivitis exhibited increased antibiotic resistance in isolated strains compared to those with healthy conjunctiva.
Impact:
- The findings highlight the potential for multiple coagulase-negative staphylococci strains with differing antibiotic resistance profiles in the conjunctiva.
- A reduction in this microbial variety may indicate an imbalance in chronic inflammatory conditions.
- Increased risk of multiresistant coagulase-negative staphylococci is associated with chronic conjunctivitis.